University of Minnesota Pig Study: HYPER-EGG® Effects

University of Minnesota Study

Effects of HYPER-EGG® on Piglet Diarrhea Prevention and Growth Performance

HYPER-EGG® is a registered Trade-Mark of J. H. Hare & Associates Ltd.

Study Overview

This study examined the effectiveness of HYPER-EGG® antibody products in preventing diarrhea and improving growth performance in piglets infected with ETEC K-88 bacteria.

Objective: Evaluate effects of HYPER-EGG K88® supplementation on diarrhea prevention and growth performance in ETEC K88-infected piglets.

Location: University of Minnesota

Subjects: Thirty 18-day old piglets (six per group)

Feeding Period: Days 1-14 post-weaning

Infection: All piglets infected orally on day 7 with 10¹² CFU of ETEC K88

Feeding Regimen

Piglets were fed nursery diets with different supplements for 14 days post-weaning, then normal diet from days 14-28.

Group	Diet Supplement	Composition
Control	EG	4Kg control egg powder (unimmunized)/T of feed
Test Group 1	ABEG 0.2%	2Kg HYPER-EGG K88®/T of feed
Test Group 2	ABEG 0.4%	4Kg HYPER-EGG K88®/T of feed
Test Group 3	ABDEX 0.2%	1Kg HYPER-EGG K88® + 1Kg Dextrose/T of feed
Test Group 4	ABDEX 0.4%	2Kg HYPER-EGG K88® + 2Kg Dextrose/T of feed

Key Findings

Diarrhea Reduction

All HYPER-EGG® groups showed reduced diarrhea incidence and severity vs. control
Statistically significant reduction in:
- ABEG 0.4% group (4Kg/T)
- ABDEX 0.4% group (2Kg HYPER-EGG® + 2Kg Dextrose/T)

Growth Performance

All test groups showed growth improvement vs. control
Significant body weight increase on days 10, 14, and 28
Day 28 weight increase: 1.7-2.5kg over control
Overall weight increase: 13-20% over control

Significant Findings

ABEG 0.4% and ABDEX 0.4% groups showed greatest improvement
During weeks 1-2, these groups had:
- Greater ADG (Average Daily Gain)
- Higher ADFI (Average Daily Feed Intake)
- Improved feed efficiency
After switching to unsupplemented diet (weeks 3-4), benefits persisted

Note: Group 3 (ABDEX 0.2%) showed slight body weight improvement but not statistically significant compared to control.

Conclusion

Feeding piglets with nursery diet supplemented with HYPER-EGG K88® antibody products from day 1 to day 14 post-weaning prevented diarrhea, reduced diarrhea severity, and improved growth performance when challenged with ETEC K88.

The most effective formulations were ABEG 0.4% (4Kg HYPER-EGG K88®/T feed) and ABDEX 0.4% (2Kg HYPER-EGG K88® + 2Kg Dextrose/T feed), which showed statistically significant benefits in both diarrhea prevention and growth metrics.